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Glossary

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Glossary of HIV Terms
and Other Definitions

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A-F

AIDS: Acquired Immunodeficiency Syndrome or Acquired Immune Deficiency Syndrome—the late stage of infection caused by the Human Immunodeficiency Virus (HIV).

Antiretroviral therapy: treatment with drugs that inhibit HIV or other types of retroviruses from multiplying in the body.

Bilirubin: a product that results from the breakdown of hemoglobin. Total and direct bilirubin are usually measured to screen for or to monitor liver or gallbladder problems.

cART: "Combination Antiretroviral Therapy" is a type of combination therapy used to treat HIV infection, which typically uses three drugs from at least two different classes of drugs (for example, nucleoside reverse transcriptase inhibitors and protease inhibitors).

CD4+ cell (T cell): one of the types of cells that your immune system uses to protect your body from infection. HIV attacks these types of cells and uses them to make more copies of HIV. CD4+ cell counts are one way your doctor tests how your body and HIV drugs are fighting HIV. The higher the number of CD4+ cells, the stronger your immune system.

Clinical trial: a research study that tests the safety of and how well a drug works in humans.

Drug resistance: the mutation of an organism, such as HIV, in such a way that it changes its sensitivity to a drug. HIV drugs are often used in combination to prevent drug resistance.

G-L

HIV: Human Immunodeficiency Virus. The virus that causes Acquired Immune Deficiency Syndrome (AIDS).

Immune system: your body's defense system against infection and certain diseases. It includes specialized cells such as B cells, T cells, and antibodies that protect the body.

Jaundice: a yellowing of the skin, eyes, and urine due to excess bilirubin in the body.

M-S

Mutation: a change in a gene or unit of hereditary material in a virus or cell that changes the process of making copies of itself.

Opportunistic infections: an infection that occurs because of a weakened immune system (for example tuberculosis, Pneumocystis jiroveci pneumonia, and thrush).

Protease inhibitor (PI): a type of anti-HIV drug that prevents the virus from making new copies of itself. PIs work by disrupting the normal function of the enzyme HIV protease and prevents virus replication. Protease inhibitors are taken in combination with other anti-HIV medications. PIs in combination therapy are able to lower the HIV level in the blood until it cannot be measured with current tests.

Regimen: a systematic treatment plan that a doctor prescribes to treat a medical condition, such as HIV.

Resistance: the mutation of an organism, such as HIV, in such a way that it changes its sensitivity to a drug. HIV drugs are often used in combination to prevent resistance.

Scleral icterus: a medical condition in which the whites of your eyes take on a yellowish color.

Side effects: unwanted events like headache, fever, and nausea that may occur when taking medications.

T-Z

Undetectable: When the amount of HIV in the blood is too low to be detected with a viral load test. The value depends on the test being used.

Viral load: the amount of HIV circulating in your body (usually measured in “copies per milliliter” or “copies/mL”). Measuring viral load is important because it determines the amount of HIV in the blood and the severity of disease.

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More Important Safety Information

SELECTED IMPORTANT SAFETY INFORMATION

Do not take REYATAZ if you are:

  • Allergic to REYATAZ or to any of its ingredients
  • Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious, life-threatening side effects or death if taken with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), ergot medicines (refer to patient information for complete list of these medicines), indinavir (Crixivan®), irinotecan (Camptosar®), lurasidone (Latuda®) if REYATAZ is used with ritonavir (Norvir®), lovastatin (Advicor®, Altoprev®, Mevacor®), midazolam (Versed®) when taken by mouth for sedation, nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®), sildenafil (Revatio®) when used for pulmonary arterial hypertension, simvastatin (Simcor®, Vytorin®, Zocor®), St. John’s wort (Hypericum perforatum), triazolam (Halcion®)

Before taking REYATAZ, tell your healthcare provider if you:

  • Have heart problems
  • Have liver problems including hepatitis B or C infection
  • Have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame and can be harmful to people with PKU.
  • Are receiving dialysis treatment
  • Have diabetes
  • Have hemophilia
  • Have any other medical conditions

Before taking REYATAZ, tell your healthcare provider if you:

  • Are pregnant or plan to become pregnant. Talk to your healthcare provider about taking REYATAZ during your pregnancy or if you are planning to become pregnant while you are taking REYATAZ.
    • Hormonal forms of birth control, such as injections, vaginal rings or implants, contraceptive patch, and some birth control pills, may not work when you are taking REYATAZ
    • After your baby is born, tell your healthcare provider if your baby’s skin or the white part of the eyes turns yellow
  • Are breastfeeding or plan to breastfeed. Do not breastfeed if you are taking REYATAZ. REYATAZ can pass into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the counter medicines, vitamins and herbal supplements. Some medicines interact with REYATAZ. Keep a list of medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • A change in the way your heart beats. You may feel dizzy or lightheaded. These could be symptoms of a heart problem.
  • Skin rash is common with REYATAZ and usually goes away within 2 weeks. Skin rash can sometimes be severe and may develop with other symptoms which can be serious. If you develop a severe rash with any of the following symptoms stop taking REYATAZ and call your healthcare provider right away: general feeling of discomfort or “flu-like” symptoms, fever, muscle or joint aches, red or inflamed eyes, blisters, mouth sores, swelling of your face, painful, warm or red lump under the skin.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • Yellowing of your skin or the white part of your eyes is common, and usually not harmful in adults and infants older than 3 months of age, but it could also be a symptom of a serious problem. This may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
  • Liver problems including hepatitis B or C may get worse when taking REYATAZ. Your healthcare provider will do blood tests before and during treatment with REYATAZ. Liver problem symptoms may include: dark “tea-colored” urine, your skin or the white part of your eyes turning yellow, light colored stools, nausea, itching, or stomach area pain.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • Kidney problemshappened in some people taking REYATAZ. Symptoms may include pain in your back or low stomach area, blood in your urine, pain when you urinate.
  • Gallbladder problems have happened in some people who take REYATAZ. Symptoms may include pain in the right or middle upper stomach area, fever, nausea and vomiting, or your skin or the white part of your eyes turning yellow.
  • Diabetes and high blood sugar have happened or worsened in some people who take protease inhibitor medicines like REYATAZ. Some people may need to start diabetes medicine or change their diabetes medicine.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • Changes in your immune system (Immune Reconstitution Syndrome). can happen when you start taking HIV-1 medicines. Tell your healthcare provider if you have any new symptoms after starting REYATAZ.
  • Changes in body fat can happen in people taking HIV-1 medicines. The exact cause and long-term health effects are not known.
  • Increased bleeding problems in people with hemophilia have happened when taking protease inhibitors like REYATAZ.

The most common side effects of REYATAZ include: nausea, headache, stomach-area pain, vomiting, trouble sleeping, numbness, tingling, or burning of hands or feet, dizziness, muscle pain, diarrhea, depression, and fever.

You should take REYATAZ capsules and oral powder once daily with food. Swallow the capsules whole; do not open the capsules. REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. Take REYATAZ exactly as your healthcare provider tells you to.

IMPORTANT SAFETY INFORMATION

Do not take REYATAZ if you are:

  • Allergic to REYATAZ or to any of its ingredients
  • Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious, life-threatening side effects or death if taken with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), ergot medicines (refer to patient information for complete list of these medicines), indinavir (Crixivan®), irinotecan (Camptosar®), lurasidone (Latuda®) if REYATAZ is used with ritonavir (Norvir®), lovastatin (Advicor®, Altoprev®, Mevacor®), midazolam (Versed®) when taken by mouth for sedation, nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®), sildenafil (Revatio®) when used for pulmonary arterial hypertension, simvastatin (Simcor®, Vytorin®, Zocor®), St. John’s wort (Hypericum perforatum), triazolam (Halcion®)

Before taking REYATAZ, tell your healthcare provider if you:

  • Have heart problems
  • Have liver problems including hepatitis B or C infection
  • Have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame and can be harmful to people with PKU.
  • Are receiving dialysis treatment
  • Have diabetes
  • Have hemophilia
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. Talk to your healthcare provider about taking REYATAZ during your pregnancy or if you are planning to become pregnant while you are taking REYATAZ.
    • Hormonal forms of birth control, such as injections, vaginal rings or implants, contraceptive patch, and some birth control pills, may not work when you are taking REYATAZ
    • After your baby is born, tell your healthcare provider if your baby’s skin or the white part of the eyes turns yellow
  • Are breastfeeding or plan to breastfeed. Do not breastfeed if you are taking REYATAZ. REYATAZ can pass into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the counter medicines, vitamins and herbal supplements. Some medicines interact with REYATAZ. Keep a list of medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • A change in the way your heart beats. You may feel dizzy or lightheaded. These could be symptoms of a heart problem.
  • Skin rash is common with REYATAZ and usually goes away within 2 weeks. Skin rash can sometimes be severe and may develop with other symptoms which can be serious. If you develop a severe rash with any of the following symptoms stop taking REYATAZ and call your healthcare provider right away: general feeling of discomfort or "flu-like" symptoms, fever, muscle or joint aches, red or inflamed eyes, blisters, mouth sores, swelling of your face, painful, warm or red lump under the skin.
  • Yellowing of your skin or the white part of your eyes is common, and usually not harmful in adults and infants older than 3 months of age, but it could also be a symptom of a serious problem. This may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
  • Liver problems including hepatitis B or C may get worse when taking REYATAZ. Your healthcare provider will do blood tests before and during treatment with REYATAZ. Liver problem symptoms may include: dark “tea-colored” urine, your skin or the white part of your eyes turning yellow, light colored stools, nausea, itching, or stomach area pain.
  • Kidney stones have happened in some people taking REYATAZ. Symptoms may include pain in your back or low stomach area, blood in your urine, pain when you urinate.
  • Gallbladder problems have happened in some people who take REYATAZ. Symptoms may include pain in the right or middle upper stomach area, fever, nausea and vomiting, or your skin or the white part of your eyes turning yellow.
  • Diabetes and high blood sugar have happened or worsened in some people who take protease inhibitor medicines like REYATAZ. Some people may need to start diabetes medicine or change their diabetes medicine.
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Tell your healthcare provider if you have any new symptoms after starting REYATAZ.
  • Changes in body fat can happen in people taking HIV-1 medicines. The exact cause and long-term health effects are not known.
  • Increased bleeding problems in people with hemophilia have happened when taking protease inhibitors like REYATAZ.

The most common side effects of REYATAZ include: nausea, headache, stomach-area pain, vomiting, trouble sleeping, numbness, tingling, or burning of hands or feet, dizziness, muscle pain, diarrhea, depression, and fever.

You should take REYATAZ capsules and oral powder once daily with food. Swallow the capsules whole; do not open the capsules. REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. Take REYATAZ exactly as your healthcare provider tells you to.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see U.S. Full Prescribing Information and Patient Information

687US1602781-02-01  10/16