REYATAZ

Indication: REYATAZ® (atazanavir) is a prescription HIV-1 (Human Immunodeficiency Virus) medicine that is used with other antiretroviral medicines to treat HIV-1 infection in adults and children 3 months of age and older and who weigh at least 10 kg (22 pounds)
• REYATAZ should not be used in children less than 3 months of age
REYATAZ does not cure HIV infection or AIDS (Acquired Immunodeficiency Syndrome). You must stay on continuous HIV therapy to control HIV infection and decrease HIV-related illnesses.

 
 
REYATAZ can help lower your viral load to undetectable. Individual results may vary. REYATAZ can help lower your viral load to undetectable. Individual results may vary. Click here REYATAZ studies have included women and men.
 

How to Take REYATAZ

The usual REYATAZ® (atazanavir) dosage for most people is one or two REYATAZ capsules once daily (see bullets below). REYATAZ must always be taken with a meal or snack and in combination with other HIV medications. Your healthcare provider will let you know the REYATAZ dosage that is right for you.

Do not take REYATAZ if you are allergic to REYATAZ or to any of its ingredients.

Read more REYATAZ Important Safety Information.

General Directions for taking once-daily REYATAZ. Follow the guidelines below to take REYATAZ correctly:

  • Take REYATAZ once every day exactly as instructed by your healthcare provider. Your healthcare provider will prescribe the amount of REYATAZ that is right for you:
    • For adults who have never taken anti-HIV medicines before, the dose is 300 mg once daily with 100 mg of Norvir® (ritonavir), once daily taken with food. For adults who are unable to tolerate ritonavir, 400 mg (two 200-mg capsules) once daily (without Norvir®) taken with food is recommended.
    • For adults who have taken anti-HIV medicines in the past, the usual dose is 300 mg plus 100 mg of Norvir® (ritonavir), once daily taken with food.
    • Pregnancy: REYATAZ 300 mg with ritonavir 100 mg once daily with food, with dosing modifications if used with certain other medicines.
    • REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. REYATAZ oral powder is not recommended for use in children who weigh less than 10 kg or who weigh 25 kg or more.
    • Children 3 months of age and older who weigh at least 10 kg (22 pounds): Your child's healthcare provider will prescribe the right dose of REYATAZ oral powder based on your child's weight. REYATAZ should not be used in children less than 3 months of age.
  • Take REYATAZ exactly as your healthcare provider tells you to.
  • Do not change your dose or stop taking REYATAZ unless your healthcare provider tells you to.
  • Stay under the care of your healthcare provider during treatment with REYATAZ.
  • REYATAZ must be used with other antiretroviral medicines.
  • Take REYATAZ 1 time each day.
  • REYATAZ comes as capsules and oral powder.
  • Take REYATAZ capsules and oral powder with food.
  • Swallow the capsules whole.Do not open the capsules.
  • REYATAZ oral powder must be mixed with food or liquid. Your child's healthcare provider will prescribe the right dose of REYATAZ based on your child's weight.
  • REYATAZ oral powder must be taken with ritonavir.
  • If you miss a dose of REYATAZ, take it as soon as you remember. Then take the next dose at your regular time. Do not take 2 doses at the same time.
  • If you take too much REYATAZ, call your healthcare provider or go to the nearest hospital emergency room right away.
  • When your supply of REYATAZ starts to run low, get more from your healthcare provider or pharmacy. It is important not to run out of REYATAZ. The amount of HIV-1 in your blood may increase if the medicine is stopped for even a short time. The virus may become resistant to REYATAZ and harder to treat.

The importance of taking HIV medications regularly

If you don't take your REYATAZ (atazanavir) and other HIV medications every day as directed by your healthcare provider, they may not work effectively. That could lead to an increase in your HIV viral load and decrease your CD4+ cell count, both of which can increase your chances of becoming sick.

Another reason to take your REYATAZ and other HIV medications correctly is that HIV can become resistant to the drugs used to treat it. If the level of an HIV medication in your body drops too low, then it can't effectively prevent HIV from reproducing. This gives the virus a chance to become resistant to that medication and possibly other medications like it.

Setting up and following a regular schedule can help you to remember to take your REYATAZ and other HIV medications once a day. Work with your healthcare provider to set up a treatment regimen that works for you.

To increase your chances of staying on schedule with REYATAZ® (atazanavir), try the following:

  • Take REYATAZ at the same time every day with a meal or a snack. If you decide to take REYATAZ with breakfast, lunch or dinner, you are more likely to keep taking it at the same time every day. You can also take REYATAZ with a light snack. Taking REYATAZ with a meal or snack helps it work better.
  • Always carry an extra dose or two, in case you're unexpectedly away from home when it's time to take your medicine.
  • When you travel, pack your medicine in your carry-on luggage.
  • Always refill prescriptions before you run out of REYATAZ (atazanavir). When your supply of REYATAZ starts to run low, it's time to call your healthcare provider or pharmacy for a refill.

It is worth repeating: It is important that you do not miss any doses of REYATAZ or your other HIV medications.

Important Safety Information

About REYATAZ

Do not take REYATAZ (atazanavir) if you are:

  • Allergic to REYATAZ or to any of its ingredients
  • Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious, life-threatening side effects or death if taken with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), ergot medicines (refer to Patient Information for complete list of these medicines), indinavir (CRIXIVAN®), irinotecan (Camptosar®), lovastatin (Advicor®, Altoprev®, Mevacor®), midazolam (Versed®) when taken by mouth for sedation, nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), rifampin (Rimactane®, Rifadin®, Rifater®, Rifamate®), sildenafil (Revatio®) when used for pulmonary arterial hypertension, simvastatin (Zocor®, Vytorin®, Simcor®), St. John's wort (Hypericum perforatum), triazolam (Halcion®)

Before taking REYATAZ, tell your healthcare provider if you:

  • Have heart problems
  • Have liver problems including hepatitis B or C infection
  • Have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame and can be harmful to people with PKU
  • Are receiving dialysis treatment
  • Have diabetes
  • Have hemophilia
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. It is not known if REYATAZ will harm your unborn baby. When taking REYATAZ with other HIV medicines called nucleoside analogues, pregnant women have developed a serious condition called lactic acidosis
    • Hormonal forms of birth control, such as injections, vaginal rings or implants, contraceptive patch, and some birth control pills, may not work when you are taking REYATAZ
    • After your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow
  • Are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV. It is not known if REYATAZ passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. REYATAZ may affect the way other medicines work and other medicines may affect how REYATAZ works and may cause serious side effects. DO NOT take the following medicines while taking REYATAZ: boceprevir (VICTRELIS®), salmeterol (SEREVENT DISKUS®) and salmeterol with fluticasone (ADVAIR DISKUS®, ADVAIR HFA®), voriconazole (VFEND®).

Tell your healthcare provider right away if you take sildenafil (VIAGRA®), tadalafil (CIALIS®, ADCIRCA®) or vardenafil (LEVITRA®, STAXYN®). People who take REYATAZ with these medicines may increase their chance of having the following side effects: lightheadedness (especially when standing), fainting, changes in vision, an erection that lasts more than 4 hours.

The above list of medicines is not complete. Please refer to the Patient Information for a list of medicines that may require your therapy to be monitored more closely or may require a change in dose or dose schedule of REYATAZ (atazanavir) or the other medicine. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • A change in the way your heart beats. You may feel dizzy or lightheaded as these could be symptoms of a heart problem
  • Skin rash is common with REYATAZ and usually goes away within 2 weeks. Skin rash can sometimes be severe and may develop with other symptoms which can be serious. If you develop a severe rash with any of the following symptoms stop taking REYATAZ and call your healthcare provider right away: general feeling of discomfort, fever, muscle or joint aches, red or inflamed eyes, blisters, mouth sores, swelling of your face, painful, warm or red lump under the skin
  • Yellowing of your skin or the white part of your eyes is common but may be a symptom of a serious problem. This may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver)
  • Liver problems including hepatitis B or C may get worse when taking REYATAZ. Your healthcare provider will do blood tests before and during treatment with REYATAZ. Liver problem symptoms may include: your skin or the white part of your eyes turning yellow, dark tea colored urine, light colored stools, nausea, itching, or stomach area pain
  • Kidney stones have happened in some people taking REYATAZ. Symptoms may include pain in your back or low stomach area, blood in your urine, pain when you urinate
  • Gallbladder problems have happened in some people who take REYATAZ. Symptoms may include pain in the right or middle upper stomach area, fever, nausea and vomiting, and your skin or the white part of your eyes turning yellow
  • Diabetes and high blood sugar have happened or worsened in some people who take protease inhibitor medicines like REYATAZ. Some people may need to start diabetes medicine or change their diabetes medicine
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Tell your healthcare provider if you have any new symptoms after starting your HIV medicine
  • Changes in body fat can happen in people taking HIV medicines. The cause and long-term health effects are not known.

The most common side effects of REYATAZ include: nausea, headache, stomach-area pain, vomiting, trouble sleeping, numbness, tingling, or burning of hands or feet, dizziness, muscle pain, diarrhea, depression, and fever

You should take REYATAZ capsules and oral powder once daily with food. Swallow the capsules whole; do not open the capsules. REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. Take REYATAZ exactly as your healthcare provider tells you to.

Click here for U.S. Full Prescribing Information, including Patient Information.

*Undetectable was defined as a viral load of less than 400 copies/mL.

Talk to your doctor

Ask your doctor about treatment that is right for you.

 

How REYATAZ fights HIV

REYATAZ is a protease inhibitor that, in combination therapy, helps prevent HIV replication. It can reduce the amount of HIV in your blood to levels that are undetectable.* REYATAZ does not cure HIV infection or AIDS. You must stay on continuous HIV therapy to control HIV infection and decrease HIV-related illnesses.