REYATAZ is a prescription medicine used to treat HIV-1 (Human Immunodeficiency Virus type 1) infection in adults, and in children who are 3 months of age and older and weigh at least 11 pounds (5 kg). A complete treatment regimen of REYATAZ in combination with other antiretroviral medicines is important to properly treat HIV.
REYATAZ will not cure HIV infection or AIDS (Acquired Immunodeficiency Syndrome), but, when taken properly, it can help reduce the amount of HIV-1 and increase the amount of infection-fighting immune cells in your blood:
REYATAZ helps prevent cells infected by HIV from producing more HIV. This reduces the amount of the virus in your body. REYATAZ as part of combination therapy is one of several treatment options your doctor may consider. REYATAZ does not cure HIV-1 infection or AIDS (Acquired Immunodeficiency Syndrome). You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses.
HIV is a virus that multiplies quickly. Untreated, it can produce billions of copies of itself every day. But HIV cannot multiply on its own. It uses the CD4+ cells of your immune system. Normally, CD4+ cells fight bacteria and viruses to keep you healthy. As HIV multiplies, it destroys CD4+ cells.
REYATAZ is in the category of HIV drugs known as protease inhibitors (PIs). PIs prevent HIV from copying itself effectively.
REYATAZ can help raise your CD4+ cells and lower your viral load to undetectable.*
Do not take REYATAZ if you are:
No. REYATAZ does not cure HIV-1 infection or AIDS (Acquired Immunodeficiency Syndrome). You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses (opportunistic infections). Opportunistic infections are infections that develop because the immune system is weak. Some of these conditions are pneumonia, herpes virus infections, and Mycobacterium avium complex (MAC) infections. It is very important that you see your healthcare provider regularly while taking REYATAZ.
REYATAZ does not lower your chance of passing HIV to other people through sexual contact, sharing needles, or being exposed to your blood. For your health and the health of others, it is important to always practice safer sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood. Never use or share dirty needles.
No. REYATAZ does not lower your chance of passing HIV to other people through sexual contact, sharing needles, or being exposed to your blood. To reduce the risks linked to sexual contact, you should get tested for sexually transmitted diseases (STDs). Let your partner know your HIV and STD status.
For your health and the health of others, it is important to always practice safer sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood.
Never share or reuse piercing, tattooing, or injection needles. If you are an injection drug user, consider seeking treatment for substance use.
Yes. REYATAZ in HIV combination therapy can be taken by adults who are starting HIV treatment for the first time.
Once-daily REYATAZ in combination therapy has been shown to be effective in helping to manage HIV. It can help lower your viral load to undetectable* and may raise your CD4+ cell count. REYATAZ does not cure HIV-1 infection or AIDS (Acquired Immunodeficiency Syndrome). You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses.
Doctors may change your HIV therapy for a variety of reasons. REYATAZ as part of combination therapy is one of several treatment options your doctor may consider.
Before you take REYATAZ, tell your healthcare
provider:
If you are pregnant or plan to become pregnant.
If you have heart or liver problems (including hepatitis B or C infection). Learn what else to discuss with your doctor
If you are receiving dialysis treatment. Learn what else to discuss with your doctor
If you have diabetes. Learn what else to discuss with your doctor
If you have hemophilia. Learn what else to discuss with your doctor
If you have any other medical conditions. Learn what else to discuss with your doctor
If you have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame and can be harmful to people with PKU.
About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines interact with REYATAZ. Keep a list of your medicines to show your healthcare provider and pharmacist. You can ask your healthcare provider or pharmacist for a list of medicines that interact with REYATAZ. Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take REYATAZ with other medicines. Learn more about possible drug interactions
Do not take REYATAZ if you are:
Serious problems can happen if you or your child takes any of the medicines listed above with REYATAZ.
Remember:
When your supply of REYATAZ starts to run low, get more from your healthcare provider or pharmacy. It is important not to run out of REYATAZ. The amount of HIV-1 in your blood may increase if the medicine is stopped for even a short time. The virus may become resistant to REYATAZ and harder to treat.
The following list of side effects is not complete. Report any new or continuing symptoms to your healthcare provider. If you have questions about side effects, ask your healthcare provider. Your healthcare provider may be able to help you manage these side effects.
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
REYATAZ use during pregnancy has not been associated with an increase in birth defects. Pregnant women have experienced serious side effects when taking REYATAZ with other HIV medicines called nucleoside analogues. You and your healthcare provider will need to decide if REYATAZ is right for you. If you use REYATAZ while you are pregnant, talk to your healthcare provider about the Antiretroviral Pregnancy Registry. And after your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow.
Do not breastfeed. REYATAZ can be passed to your baby in your breast milk and it is not known whether it could harm your baby. Also, mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk.
Over time, HIV can become resistant to HIV drugs. When patients develop resistance to a drug in a certain class (for example, REYATAZ, which is a protease inhibitor [PI]), they often become resistant to many or all of the drugs in that class.
Learn more about how REYATAZ works
Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious or life-threatening side effects, or death if taken with the following medicines:
Active Ingredients: atazanavir sulfate
Inactive Ingredients:
*Having an undetectable viral load means that your viral load is below what a lab test can detect. The value depends on the test being used. In REYATAZ clinical trials, undetectable was defined as a viral load of fewer than 400 copies/mL or 50 copies/mL depending on the trial.
Ask your HCP what the viral load cut-off for undetectable is for the test used for you.
Before taking REYATAZ, tell your healthcare provider about all of your medical conditions, including if you:
Before taking REYATAZ, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Some medicines interact with REYATAZ. Keep a list of medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
Do not take REYATAZ if you are:
Before taking REYATAZ, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Some medicines interact with REYATAZ. Keep a list of medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
The most common side effects of REYATAZ include: nausea, headache, stomach-area pain, vomiting, trouble sleeping, numbness, tingling, or burning of hands or feet, dizziness, muscle pain, diarrhea, depression, and fever.
You should take REYATAZ capsules and oral powder once daily with food. Swallow the capsules whole; do not open the capsules. REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. Take REYATAZ exactly as your healthcare provider tells you to.
Please see Patient Information in the Full Prescribing Information.