REYATAZ Drug Interactions

Do not take REYATAZ if you take the following medicines (not all brands may be listed). Tell your healthcare provider about all the medicines you take. REYATAZ may cause serious, life-threatening side effects or death when used with these medicines.

• Ergot medicines: dihydroergotamine, ergonovine, ergotamine, and methylergonovine such as CAFERGOT^®, MIGRANAL^®, D.H.E. 45^®, ergotrate malate, METHERGINE^®, and others used to treat migraine headaches.
• HALCION^® (triazolam, used for insomnia).
• VERSED^® (midazolam, used for sedation).
• ORAP^® (pimozide, used for Tourette's disorder).
• PROPULSID^® (cisapride, used for certain stomach problems).

Do not take the following medicines with REYATAZ because of possible serious side effects:

• CAMPTOSAR^® (irinotecan, used for cancer).
• CRIXIVAN^® (indinavir, used for HIV infection). Both REYATAZ and CRIXIVAN sometimes cause increased levels of bilirubin in the blood.
• Cholesterol-lowering medicines MEVACOR^® (lovastatin) or ZOCOR^® (simvastatin).

Do not take the following medicines with REYATAZ because they may lower the amount of REYATAZ in your blood. This may lead to an increased HIV viral load. Resistance to REYATAZ or cross-resistance to other HIV medicines may develop.

• Rifampin (also know as RIMACTANE^®, RIFADIN^®, RIFATER^®, or RIFAMATE^®, used for tuberculosis).
• St. John's wort (Hypericum perforatum), an herbal product sold as a dietary supplement, or products containing St. John's wort.

Do not take the following medicine if you are taking REYATAZ and NORVIR^® together:

• VFEND^® (voriconazole).

The following medicines may require your healthcare provider to monitor your therapy more closely:

• CIALIS^® (tadalafil), LEVITRA^® (vardenafil) or VIAGRA^® (sildenafil). REYATAZ may increase the chances of serious side effects that can happen with CIALIS, LEVITRA or VIAGRA. Do not use CIALIS, LEVITRA or VIAGRA while taking REYATAZ unless your healthcare provider tells you it is okay.
• LIPITOR^® (atorvastatin) or CRESTOR^® (rosuvastatin). There is an increased chance of serious side effects if you take REYATAZ with these cholesterol-lowering medicines.
• Medicines for abnormal heart rhythm: CORDARONE^® (amiodarone), lidocaine, quinidine (also known as CARDIOQUIN^®, QUINDEX^®, and others).
• VASCOR^® (bepridil, used for chest pain).
• COUMADIN^® (warfarin).
• Tricyclic antidpressants such as ELAVIL^® (amitriptyline), NORPRAMIN^® (desipramine), SINEQUAN^® (doxepin), SURMONTIL^® (trimipramine), TOFRANIL^® (imipramine), or VIVACTIL^® (protripyline).
• Medicines to prevent organ transplant rejection: SANDIMMUNE^® or NEORAL^® (cyclosporin), RAPAMUNE^® (sirolimus), or PROGRAF^® (tacrolimus).
• The antidepressant trazodone (DESYREL^® and others).
• Fluticasone propionate (ADVAIR^®, FLONASE^®, FLOVENT^®), given by nose or inhaled to treat allergic symptoms or asthma. Your doctor may choose not to keep you on fluticasone, especially if you are taking NORVIR^®.

The following medicines may require a change in dose or dose schedule of either REYATAZ or the other medicine:

• FORTOVASE^®, INVIRASE^® (saquinavir).
• NORVIR^® (ritonavir).
• SUSTIVA^® (efavirenz).
• Antacids or buffered medicines.
• VIDEX^® (didanosine).
• VIREAD^® (tenofovir disoproxil fumarate).
• MYCOBUTIN^® (rifabutin).
• Calcium channel blockers such as CARDIZEM^® or TIAZAC^® (diltiazem), COVERA-HS^® or ISOPTIN SR^® (verapamil) and others.
• BIAXIN^® (clarithromycin).
• Medicines for indigestion, heartburn or ulcers such as AXID^® (nizatidine), PEPCID AC^® (famotidine), TAGAMET^® (cimetidine) or ZANTAC^® (ranitidine), ACIPHEX^® (rabeprazole), NEXIUM^® (esomeprazole), PREVACID^® (lansoprazole), PRILOSEC^® (omeprazole), or PROTONIX^® (pantoprazole).

Women who use birth control pills or 'the patch' should choose a different kind of contraception. REYATAZ may affect the safety and effectiveness of birth control pills or the patch. Talk to your healthcare provider about choosing a contraceptive that will work for you. REYATAZ does not cure HIV or help prevent passing HIV to others.

Remember:

1. Know all the medicines you take.
2. Tell your healthcare provider about all the medicines you take.
3. Do not start a new medicine without talking to your healthcare professional.

* "Undetectable" is defined as a viral load that is too low to be picked up by a particular test. Typically, it is a viral load of less than 400 or 50 copies/mL (depending on test used).