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IMPORTANT INFORMATION ABOUT REYATAZ® (atazanavir sulfate)
INDICATION: REYATAZ is a prescription medicine used in combination with other medicines to treat people who are infected with the human immunodeficiency virus (HIV). REYATAZ has been studied in 48-week trials in both patients who have taken or have never taken anti-HIV medicines.
REYATAZ does not cure HIV or help prevent passing HIV to others.
IMPORTANT SAFETY INFORMATION:
Do not take REYATAZ if you are taking the following medicines: rifampin, Camptosar®(irinotecan), Versed®(midazolam), Halcion®(triazolam), ergot medicines, Propulsid®(cisapride), St. John's wort (Hypericum perforatum), Mevacor®(lovastatin), Zocor®(simvastatin), Orap®(pimozide), or Crixivan®(indinavir).
Speak with your healthcare provider before taking the following medicines if you are taking REYATAZ: Viagra®(sildenafil), Levitra®(vardenafil), Cialis®(tadalafil), Vfend®(voriconazole), AcipHex®(rabeprazole), Nexium®(esomeprazole), Prevacid®(lansoprazole), Prilosec®(omeprazole), Protonix®(pantoprazole), Axid®(nizatidine), Pepcid AC®(famotidine), Tagamet®(cimetidine), or Zantac®(ranitidine), Advair®(fluticasone propionate and salmeterol inhalation powder),
Flonase®(fluticasone propionate), or Flovent®(fluticasone propionate). The above lists of medicines are not complete. Discuss all prescription and non-prescription medicines, vitamin and herbal supplements, or other health preparations you are taking or plan to take with your healthcare provider.
Tell your healthcare provider right away if you have any side effects, symptoms, or conditions, including the following:
- A change in the way your heart beats may occur and could be a symptom of a heart problem.
- Mild Rash (redness and itching) without other symptoms sometimes occurs in patients taking REYATAZ, most often in the first few weeks after the medicine is started, and usually goes away within two weeks with no change in treatment.
- Severe Rash has occurred in a small number of patients taking REYATAZ. This type of rash is associated with other symptoms which could be serious and potentially cause death. If you develop a rash with any of the following symptoms, stop using REYATAZ and call your healthcare provider right away:
- –Shortness of breath
- –General ill-feeling or "flu-like" symptoms
- –Fever
- –Muscle or joint aches
- –Conjunctivitis (red or inflamed eyes, like "pink-eye")
- –Blisters
- –Mouth sores
- –Swelling of your face
- Yellowing of the skin and/or eyes may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
- If you have liver disease, including hepatitis B or C, your liver disease may get worse when you take anti-HIV medicines like REYATAZ.
- Kidney stones have been reported in patients taking REYATAZ. Signs or symptoms of kidney stones include pain in your side, blood in your urine, and pain when you urinate.
- Diabetes and high blood sugar may occur in patients taking protease inhibitor medicines like REYATAZ.
- Changes in body fat have been seen in some patients taking anti-HIV medicines. The cause and long-term effects are not known at this time.
- Some patients with hemophilia have increased bleeding problems with protease inhibitor medicines like REYATAZ.
Other side effects of REYATAZ taken with other anti-HIV medicines include: nausea, headache, stomach pain, vomiting, diarrhea, depression, fever, dizziness, trouble sleeping, numbness, and tingling or burning of hands or feet.
You should take REYATAZ once daily with food (a meal or snack). You should take REYATAZ and your other anti-HIV medicines exactly as instructed by your healthcare provider.
REYATAZ is one of several treatment options your doctor may consider.
Click here for US Full Prescribing Information including Patient Information.