REYATAZ

What is REYATAZ® (atazanavir)?

REYATAZ is a prescription HIV-1 (Human Immunodeficiency Virus-type 1) medicine that is used with other antiretroviral medicines to treat HIV-1 infection in adults and children 3 months of age and older and who weigh at least 11 pounds (5 kg).

• REYATAZ should not be used in children less than 3 months of age

REYATAZ does not cure HIV-1 infection or AIDS (Acquired Immunodeficiency Syndrome). You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses.

 
 
REYATAZ can help lower your viral load to undetectable. Individual results may vary. REYATAZ can help lower your viral load to undetectable. Individual results may vary. Click here REYATAZ studies have included women and men.
 

How REYATAZ Fights HIV

REYATAZ® (atazanavir) is a protease inhibitor (PI), a type of HIV medication that works by disrupting the normal function of HIV protease, an enzyme necessary for HIV to reproduce itself.

In combination therapy, REYATAZ can help lower your viral load to undetectable* and help raise your CD4+ cell count. Lower viral load means less virus destroying CD4+ cells. REYATAZ does not cure HIV infection or AIDS. You must stay on continuous HIV therapy to control HIV infection and decrease HIV-related illnesses.

Selected Important Safety Information

About REYATAZ® (atazanavir)

Do not take REYATAZ if you are:

  • Allergic to REYATAZ or to any of its ingredients
  • Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious, life-threatening side effects or death if taken with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), ergot medicines (refer to patient information for complete list of these medicines), indinavir (CRIXIVAN®), irinotecan (Camptosar®), lovastatin (Advicor®, Altoprev®, Mevacor®), midazolam (Versed®) when taken by mouth for sedation, nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®), sildenafil (Revatio®) when used for pulmonary arterial hypertension, simvastatin (Simcor®, Vytorin®, Zocor®), St. John's wort (Hypericum perforatum), triazolam (Halcion®)

Read more REYATAZ Important Safety Information including additional information on drug interactions.

How HIV attacks the immune system

CD4+ cells are an important part of your immune system. Sometimes, they are called
"T-cells." These cells lead the attack against infections from viruses and bacteria.

When a person has HIV, the cells most often infected with HIV are healthy CD4+ cells. The virus uses the CD4+ cells to create more copies of itself. As it multiplies, HIV destroys CD4+ cells. Left untreated, HIV can overpower your immune system.

Healthcare providers measure CD4+ cell count as part of your HIV treatment. If your CD4+ cell count goes down, it is a sign that the immune system is being weakened and the likelihood of other additional illnesses will be higher.

Once-daily REYATAZ® (atazanavir) in combination therapy can help lower your viral load to undetectable* and raise your CD4+ count. Ask your doctor if REYATAZ is right for you.

REYATAZ is a protease inhibitor that helps prevent HIV from copying itself correctly. REYATAZ does not cure HIV or AIDS and you may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections.

Fusion Inhibitors and Entry Inhibitors–help shield the CD4+ cell by blocking HIV from entering it

Nucleoside Reverse Transcriptase Inhibitors (NRTI)–create faulty building blocks that stall HIV from copying itself

Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)–bind and disable the reverse transcriptase protein that HIV needs to replicate

Integrase Inhibitors–help prevent virus replication by disabling the integrase protein so it can't put the virus's genes into the CD4+ cell

Protease Inhibitors (PI)–interfere with HIV's ability to copy itself correctly by disabling the protease protein

Important Safety Information About

REYATAZ® (atazanavir)

Do not take REYATAZ if you are:

  • Allergic to REYATAZ or to any of its ingredients
  • Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious, life-threatening side effects or death if taken with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), ergot medicines (refer to patient information for complete list of these medicines), indinavir (CRIXIVAN®), irinotecan (Camptosar®), lovastatin (Advicor®, Altoprev®, Mevacor®), midazolam (Versed®) when taken by mouth for sedation, nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®), sildenafil (Revatio®) when used for pulmonary arterial hypertension, simvastatin (Simcor®, Vytorin®, Zocor®), St. John's wort (Hypericum perforatum), triazolam (Halcion®)

Before taking REYATAZ, tell your healthcare provider if you:

  • Have heart problems
  • Have liver problems including hepatitis B or C infection
  • Have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame and can be harmful to people with PKU.
  • Are receiving dialysis treatment
  • Have diabetes
  • Have hemophilia
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. Talk to your healthcare provider about taking REYATAZ during your pregnancy or if you are planning to become pregnant while you are taking REYATAZ.
    • Hormonal forms of birth control, such as injections, vaginal rings or implants, contraceptive patch, and some birth control pills, may not work when you are taking REYATAZ
    • After your baby is born, tell your healthcare provider if your baby's skin or the white part of the eyes turns yellow
  • Are breastfeeding or plan to breastfeed. Do not breastfeed if you are taking REYATAZ. REYATAZ can pass into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Some medicines interact with REYATAZ. Keep a list of medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:

  • A change in the way your heart beats. You may feel dizzy or lightheaded. These could be symptoms of a heart problem.
  • Skin rash is common with REYATAZ and usually goes away within 2 weeks. Skin rash can sometimes be severe and may develop with other symptoms which can be serious. If you develop a severe rash with any of the following symptoms stop taking REYATAZ and call your healthcare provider right away: general feeling of discomfort or “flu-like” symptoms, fever, muscle or joint aches, red or inflamed eyes, blisters, mouth sores, swelling of your face, painful, warm or red lump under the skin.
  • Yellowing of your skin or the white part of your eyes is common, and usually not harmful in adults and infants older than 3 months of age, but it could also be a symptom of a serious problem. This may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
  • Liver problems including hepatitis B or C may get worse when taking REYATAZ. Your healthcare provider will do blood tests before and during treatment with REYATAZ. Liver problem symptoms may include: dark “tea-colored” urine, your skin or the white part of your eyes turning yellow, light colored stools, nausea, itching, or stomach area pain.
  • Kidney stones have happened in some people taking REYATAZ. Symptoms may include pain in your back or low stomach area, blood in your urine, pain when you urinate.
  • Gallbladder problems have happened in some people who take REYATAZ. Symptoms may include pain in the right or middle upper stomach area, fever, nausea and vomiting, or your skin or the white part of your eyes turning yellow.
  • Diabetes and high blood sugar have happened or worsened in some people who take protease inhibitor medicines like REYATAZ. Some people may need to start diabetes medicine or change their diabetes medicine.
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Tell your healthcare provider if you have any new symptoms after starting REYATAZ.
  • Changes in body fat can happen in people taking HIV-1 medicines. The exact cause and long-term health effects are not known.
  • Increased bleeding problems in people with hemophilia have happened when taking protease inhibitors like REYATAZ.

The most common side effects of REYATAZ include: nausea, headache, stomach-area pain, vomiting, trouble sleeping, numbness, tingling, or burning of hands or feet, dizziness, muscle pain, diarrhea, depression, and fever.

You should take REYATAZ capsules and oral powder once daily with food. Swallow the capsules whole; do not open the capsules. REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. Take REYATAZ exactly as your healthcare provider tells you to.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Click here for U.S. Full Prescribing Information, including Patient Information.

*Undetectable was defined as a viral load of less than 400 copies/mL

Talk to your doctor

Ask your doctor about treatment that is right for you.

 

Taking REYATAZ

REYATAZ is a protease inhibitor that you take once daily with a meal or snack as part of a regimen of HIV medications. Do not take REYATAZ if you are allergic to REYATAZ or to any of its ingredients.

 

Managing your care

If you have HIV, it is important to focus on more than your medications.